Thesis on microemulsion pdf best cover letter for management position professional paper editor site for school. Lecithinlinker microemulsionbased gels for drug delivery xiao yue xuan master of applied science department of chemical engineering and applied chemistry university of toronto. Microemulsion is a nanoparticle synthesis technique in which two immiscible fluids such as water in oil wo, oil in water ow or water in supercritical carbon dioxide wsc co2 are thermodynamically stabilized with the aid of a surfactant. Sunscreens photostability, formulation and skin penetration jutta kockler, approbierte apothekerin germany certified pharmacist this thesis is submitted for the degree of doctor of philosophy at james cook university school of pharmacy and molecular sciences discipline of. Formulation and evaluation of microemulsion based topical hydrogel containing lornoxicam biswajit biswal1, nabin karna 1, jyotiranjan nayak2, vivek joshi 1dept. Therefore, microemulsion has been reported to be ideal delivery of drugs such as steroids, hormones, diuretic and antibiotics. Mandal baroda college of pharmacy, vadodara, india.
The majority of microemulsions use oil and water as immiscible liquid pairs. A thesis presented in partial fulfilment of the requirements. Synthesis and characterization of linipo4 nanocrystals via a microemulsion method as a new class of electocatalyst for oxygen reduction titleinfo id t2. For phase behavior investigation, studied surfactant was oleth10, the studied oils were silicone. For modified lecithin, the microemulsion contains at least one metal chelate complex, at least one surfactant such as an anionic surfactant, modified lecithin, water, and optionally at least one alcohol. They described these systems as optically isotropic, transparent oil and water dispersions of droplets whose diameters were somewhat greater than swollen micelles. Microemulsion me formulation how to develop a microemulsion me formulation microemulsion are, by definition, optically clear dispersion of one physically incompatible liquid into another. This unpublished thesisdissertation is of the author andor third parties. If a cosurfactant is used, it may sometimes be represented at a fixed. The microemulsion systems of polyoxyethylene10oleyl etheroilwater have been studied. Microemulsion, palm oil, thermal analysis, tween 80, alcohol. Microemulsions either ow or wo, both have been used as mobile phases for separation in microemulsion high performance liquid chromatography mehplc, a newer technique used to separate, resolve, detect, and quantify solutes within a given sample. Both ow and wo microemulsion can be used for parenteral delivery.
My thesis work explores two different types of waterinoil microemulsion. This thesis is presented as part of the requirements for the award of. Microemulsion can be defined as a system of water, oil and an amphiphile which is a single optically isotropic and thermodynamically stable liquid solution 1. Preparation of nano and microemulsions using phase. Progress in microemulsion characterization sciencedirect. This thesis aimed to investigate the phase behavior of systems composed of cosmetic acceptable components and to prepare and characterize nicotinamideloaded microemulsions as well as microemulsionbased gels. Microemulsion route to the synthesis of nanoparticles article pdf available in pure and applied chemistry 8011. Volume 5 number 4 aug 2015 114 available online at. Linkerbased lecithin microemulsions as transdermal drug.
Sz ucs maria, budai szabolcs, er os istvan, gelemulsion systems i. Stability and characterisation of emulsions in the presence of colloidal particles and surfactants by roman pichot a thesis submitted to the university of birmingham. Microemulsion based gel has been increased interest during recent years in the use of topical vehicle systems that could modify drug permeation through the skin. Microemulsion formation is spontaneous and does not require much energy. Formulation and evaluation of microemulsion based topical. Physicalchemical characterisation, acta pharmaceutica hungarica 78 2008 1121 if. This book provides an assessment of some issues influencing the characteristics and performance of the microemulsions, as well as their main types of applications. Isbn 9789535102472, pdf isbn 9789535149712, published 20120316. Sunscreens photostability, formulation and skin penetration jutta kockler, approbierte apothekerin germany certified pharmacist this thesis is submitted for the degree of doctor of philosophy at james cook university school of pharmacy and molecular sciences discipline of pharmacy february 2014. Different type of topical delivery systems of flucona zole, including emulsion, emulgel, lipogel, and thickened microemulsionbased hydrogel have been evaluated to. The rapidly increasing number of applications for microemulsions has kept this relatively old topic still at the top point of research themes. Formulation and characterization of microemulsion system.
Microemulsion domains are usually characterized by constructing ternaryphase diagrams. Thesis on microemulsion pdf, custom definition essay editing site us, how to write referral for universities, custom letter ghostwriters services gb. I am incredibly fortunate to have professor acosta as. A potential novel drug delivery system jaspreet kaur saini 1, ujjwal nautiyal 1, senthil kumar m 1, devendra singh 2, firoz anwar 3 1department of pharmaceutics, himachal institute of pharmacy, paonta sahib, himachal pradesh, india. The microemulsion system thus, shows a structural change from oil continuous system to water continuous, which has higher viscosities than the former 34. Preparation of nicotinamide microemulsions and formulation. Hoar and schulman stimulated the interest of researchers in microemulsions in 1943 when they found that the addition of. The term microemulsion first entered the scientific vernacular in 1959, through the work of jack h.
Preparation of nano and microemulsions using phase inversion. Stability, acta pharmaceutica hungarica 78 2008 2330 if. This thesis aimed to investigate the phase behavior of systems composed of cosmetic acceptable components and to prepare and characterize nicotinamideloaded microemulsions as well as microemulsion based gels. This may be considered as an extension of w insors classification form ing the fifth category. The intellectual property rights of the author or third parties in respect. Many of the pages are now actually obtainable in printerfriendly pdf format. The aim of the present study was to design novel ow microemulsion of glimepiride and to study its. Use of a large concentration of surfactant and cosurfactant necessary for stabilizing the nanodroplets. The medium chain triglycerides mct and retinyl palmitate mixture 1. Microemulsion formulations offer the several benefits over conventional oral formulation for oral administration including increased absorption, improved clinical potency and decreased drug toxicity 51. For viscosity determination of microemulsion based hydrogel, 175 g of microemulsion based hydrogel was filled in a 250 ml beaker and the viscosity was measured by using spindle number lv4. Effect of water content on the viscosity of microemulsion formulations. Preparation of nano and microemulsions using phase inversion and emulsion titration methods.
Upon mild agitation followed by dilution in aqueous media, such as gastrointestinal gi fluids, the systems can form fine oil in water ow microemulsions which usually have a droplet size less than 100 nm. Synthesis and characterization of linipo4 nanocrystals via. Microemulsions an introduction to properties and applications. Record the volumes of water v belonging to the emulsion, gel and. Such a novel technique has considerable application in the fields of analytical chemistry and. Preparation and characterization of protein loaded. A microemulsion forming systems is shown in figure 1. Definition and history one of the best definitions of microemulsions is from danielsson and lindman 1 a microemulsion is a system of water, oil and an amphiphile which is a single optically isotropic and thermodynamically stable liquid solution. The amount of naflu present in each sample was determined from a standard. Dec 28, 2015 microemulsion is an isotropic mixture of oil, surfactant, cosurfactant and drug. Microemulsion formulations have distinct advantages over macroemulsion systems when delivered parenterally because of the fine particle microemulsion is cleared more slowly than the coarse particle emulsion and, therefore, have a longer residence time in the body. Description this thesis examines the electrocatalytic properties shown by lithium nickel phosphate nanoparticles for the oxygen reduction reaction orr, an important cathode reaction in fuel cells. Therefore, the present study was conceived to develop bawo 4 nanoparticles in a waterinoil wo microemulsion system composed of 1,4dioxane and water. In chapter 1 a short introduction about the background, various aspects and applications.
Masters degree at toledo and for being a member of my thesis committee. Stability and characterisation of emulsions in the. Budai szabolcs, sz ucs maria, er os istvan, gelemulsion systems ii. The samples were also analysed for their particle size and size distribution, viscosity, conductivity and birefringence. Silica coating of monodisperse hydrophobic magnetite nanoparticles through reverse microemulsion techniques submitted by zeynep ergul in partial fulfillment of the requirements for the degree of master of science in micro and nanotechnology department, middle east technical university by, prof. Characterization of microemulsions prepared using isopropyl. The objective of this study was to prepare and characterize a stable microemulsion system for encapsulating a parathyroid hormone pth.
The present invention provides a storage stable microemulsion formulation for modified lecithin as well as other materials. The composition of the different formulated microemulsion batches a1a3 is shown in table 2. Therefore, one should characterize microemulsion structures in detail for improving novel and effective techniques and applications. Nov 21, 2014 the microemulsion definition provided by danielson and lindman in 1981 will be used as the point of reference. For viscosity determination of microemulsionbased hydrogel, 175 g of microemulsionbased hydrogel was filled in a 250 ml beaker and the viscosity was measured by using spindle number lv4. Oil and water are immiscible and they separate into two phases when mixed, each saturated with traces of the other component capek, 1999. Development and evaluation of novel biocompatible microemulsion. Formulation and characterization of microemulsion based gel. Billy took it the seasonal final tournament down on january 10th at ri ra irish pub. Lecithinlinker microemulsion based gels for drug delivery xiao yue xuan master of applied science department of chemical engineering and applied chemistry university of toronto 2011 abstract microemulsions have gained interest from the pharmaceutical industry due to their ability to co. Temperature sweeps involve the analysis of a sample. Interfacial tension, measurement, effect of surfactant on. Basic aspects of microemulsion microemulsion are fluid, transparent, thermodynamically stable oil and water system and stabilized by a surfactant usually in conjunction with cosurfactant.
Pdf microemulsion route to the synthesis of nanoparticles. Pdf the objective of our investigation was to design a thermodynamically stable. One of the most important fundamental questions in this eld is the relation between the properties of the surfactant monolayer at wateroil interface and those of microemulsions. Microemulsions may be defined as oil dispersed in water or water dispersed in oil. The work of dissertation preparation was a daunting. This thesis is brought to you for free and open access by digital. The overall objective of this thesis was to develop stable. Formulation and characterization of microemulsion based. Further study on the behavior of microemulsion in porous medium is currently being conducted tcholakova department of chemical engineering, faculty of chemistry, sofia university, sofia, bulgaria lecture at cost p21 training school physics of droplets. The use of microemulsion as delivery systems can improve the efficacy of a drug, allowing the total dose to be reduced and thus minimizing side effects. Different type of topical delivery systems of flucona zole, including emulsion, emulgel, lipogel, and thickened microemulsion based hydrogel have been evaluated to. The microemulsion system is turning to be more viscous with addition of water and thus may help in the slow diffusing of drug at infinite dilution.
The phase behaviour and nano and microemulsion formation of the ternary mixtures prepared were characterised by visual observation for their phase separation and optical clarity e. The best surfactant to cosurfactant ratio for microemulsion preparation was 3. Sep 09, 2009 preparation of the microemulsion base and microemulsion systems containing different concentrations of salicylic acid. Formulation of hydrogel thickened microemulsion carbopol 934p, hpmc k15m and xanthan gum was hydrated in fixed amount of water for at least 4 h and then. To get the therapeutic amount pth loaded into the microemulsion system without compromising the stability of microemulsion system, the key objective of this work was to solubilize higher percentage of aqueous. Simultaneous presenceof two microemulsion phases, one in contact with water and the other in contact with oil is also possible. The second part of this study takes advantage of the lidocaine adsorbed in the skin with the linkerbased lecithin microemulsion as reservoir for in situ skin patches. For other materials, the microemulsion contains all above plus one. Preparation and evaluation of microemulsion systems. We have made a thorough market research before introducing a breakthrough new system with updated policies. New formulation strategies in topical antifungal therapy. Pdf development of microemulsion based formulation to improve.
An me gel base composed of 35% ipm, 20% water, and 45% tween 80. Micelles, microemulsions, liquid crystals, and the. Interfacial tension, measurement, effect of surfactant on oil. Thesis formulation and investigation of gelemulsions. The main drawback to the continued development of fuel cells is the relatively slow rate of the orr compared with a reaction at the anode of a fuel cell.
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